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| 5,10-Methylenetetrahydrofolic acid ： ウィキペディア英語版 |
5,10-Methylenetetrahydrofolate
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5,10-Methylenetetrahydrofolate (5,10-CH2-THF) is the substrate used by the enzyme methylenetetrahydrofolate reductase (MTHFR)〔(【引用サイトリンク】 url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4524 )〕 to generate 5-methyltetrahydrofolate (5-MTHF, or levomefolic acid).
5,10-CH2-THF can also be used as a coenzyme in the biosynthesis of thymidine. To be specific, it is the C1-donor in the reactions catalyzed by thymidylate synthase and thymidylate synthase (FAD). It also acts as a cofactor in the synthesis of serine from glycine via the enzyme serine hydroxymethyl transferase.
==See also==
* Serine hydroxymethyltransferase (SHMT)
* 5,10-Methenyltetrahydrofolate
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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